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Use of a retinoid antagonist or negative hormone having a formula Image in the manufacture of a medicament for ameliorating the toxicity or undesired side effects, resulting from using a retinoid compound to a mammal, 142 wherein X is S,O, or NR' where R' is H or alkyl of 1 to 6 carbons, or X is [C(R1)2]n where R1 is H or alkyl of 1 to 6 carbons, and n is an integer between 0 and 2; R2 is hydrogen, lower alkyl of 1 to 6 carbon F, Cl, Br, I, CF3, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons; R3 is hydrogen, lower alkyl of 1 to 6 carbons or F; m is an integer having the value of 0 - 3; o is an integer having the value of 0 - 3; Z is -C=C- ; -N=N-, -N=CR1-, -CR1=N, -(CR1=CR1)n'- where n' is an integer having the value 0 - 5, -CO-NR1-, -CS-NR1-, -NR1-CO, -NR1-CS, -CSO-; or -OCS-; 143 Y is phenyl, naphthyl, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrrazolyl, said phenyl and heteroaryl groups being optionally substituted with one or two R2 groups, or when Z is -(CR1=CR1)n'- and n' is 3, 4 or 5 then Y represents a direct valence bond between said (CR1=CR1)n' group and B; A is (CH2)q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R18, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, CR7OR13O, or tri-lower alkylsilyl, where R7 is an alkyl, cycloalkyl or alkenyl group containing 2 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, and R14 is (R15)r-phenyl, (R15)r-naphthyl, or (R15)r- heteroaryl where the heteroaryl group has 1 to 3 heteroatoms selected from the group consisting of O, S and N, r is an integer having the values of 0 - 5, and R15 is independently H, F, Cl, Br, I, NO2, N(R8)2, NH(R8)COR8, NR8CON(R8)2, OH, OCOR8, OR8, CN, an alkyl group having 1 to 10 carbons, fluoro substituted alkyl group having 1 to 10 carbons, an alkenyl group having 2 to 10 carbons and 1 to 3 double bonds, alkynyl group having 2 to 10 carbons and 1 to 3 triple bonds, or a trialkylsilyl or trialkylsilyloxy group where the alkyl groups independently have 1 to 6 carbons. 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Bodybuilding testosterone uk, cosa aumenta il testosterone

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